Variable heavy-chain gene analysis of follicular lymphomas: subclone selection rather than clonal evolution over time
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چکیده
منابع مشابه
Variable heavy-chain gene analysis of follicular lymphomas: subclone selection rather than clonal evolution over time.
To investigate B-cell receptor evolution in follicular lymphomas (FLs), immunoglobulin variable heavy chain (V(H)) gene regions of 3 FLs were analyzed at different time points. One FL with a high somatic mutation load and intraclonal V(H) gene diversity was investigated in situ. V(H) gene transcripts were amplified and sequenced from samples of approximately 50 tumor cells isolated from frozen ...
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ژورنال
عنوان ژورنال: Blood
سال: 2001
ISSN: 1528-0020,0006-4971
DOI: 10.1182/blood.v98.1.238